Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …
[HTML][HTML] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
Recent progress in psychiatric genetics—some hope but no hype
SF Stoltenberg, M Burmeister - Human molecular genetics, 2000 - academic.oup.com
The reputation of the field of psychiatric genetics has recently become tarnished in the view
of many human geneticists. Too many linked loci were claimed and withdrawn, too many …
of many human geneticists. Too many linked loci were claimed and withdrawn, too many …
Psychiatric genetics and the structure of psychopathology
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …
observation. The modern DSM has relied on a consensus of experts to define categorical …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Assessing the evidence for shared genetic risks across psychiatric disorders and traits
Genetic influences play a significant role in risk for psychiatric disorders, prompting
numerous endeavors to further understand their underlying genetic architecture. In this …
numerous endeavors to further understand their underlying genetic architecture. In this …
Psychiatric genetics: progress amid controversy
Several psychiatric disorders—such as bipolar disorder, schizophrenia and autism—are
highly heritable, yet identifying their genetic basis has been challenging, with most …
highly heritable, yet identifying their genetic basis has been challenging, with most …
What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn
KS Kendler - Molecular psychiatry, 2013 - nature.com
Psychiatric genetics has taught us a great deal about the nature of psychiatric disorders.
Traditional family, twin and adoption studies have demonstrated the substantial role of …
Traditional family, twin and adoption studies have demonstrated the substantial role of …
Emerging phenotyping strategies will advance our understanding of psychiatric genetics
S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …
identified numerous significant loci. Whereas these studies initially depended on cohorts …
The genetics of neuropsychiatric disorders
NJ Bray, MC O'Donovan - Brain and neuroscience …, 2018 - journals.sagepub.com
Neuropsychiatric disorders are complex conditions with poorly defined neurobiological
bases. In recent years, there have been significant advances in our understanding of the …
bases. In recent years, there have been significant advances in our understanding of the …