Specific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis E

D Harms, M Choi, K Allers, B Wang, H Pietsch… - Scientific Reports, 2020 - nature.com
Hepatitis E virus (HEV) genotypes 3 and 4 (HEV-3, HEV-4) infections are an emerging
public health issue in industrialized countries. HEV-3 and− 4 are usually self-limiting but can …

Specific plasma MicroRNA signatures underlying the clinical outcomes of hepatitis E virus infection

MI Costafreda, S Sauleda, M Riveiro-Barciela… - Microbiology …, 2023 - Am Soc Microbiol
The pathogenic mechanisms determining the diverse clinical outcomes of HEV infection (eg,
self-limiting versus chronic or symptomatic versus asymptomatic) are not yet understood …

Hepatitis E virus‐encoded microRNA promotes viral replication by inhibiting type I interferon

Z Qian, C Yang, L Xu, HK Mickael, S Chen… - The FASEB …, 2022 - Wiley Online Library
Abstract MicroRNAs (miRNAs), the non‐coding RNAs of~ 22 nucleotides (nt) in length, play
a vital role in regulating viral replication. Hepatitis E virus (HEV), a single‐stranded RNA …

Positive regulation of hepatitis E virus replication by microRNA-122

B Haldipur, PL Bhukya, V Arankalle, K Lole - Journal of virology, 2018 - Am Soc Microbiol
The molecular mechanisms of liver pathology and clinical disease in hepatitis E virus (HEV)
infection remain unclear. MicroRNAs (miRNAs) are known to modulate viral pathogenesis …

Micro RNAs—The Small Big Players in Hepatitis E Virus Infection: A Comprehensive Review

E Golkocheva-Markova - Biomolecules, 2022 - mdpi.com
The molecular mechanism of hepatitis E virus (HEV) pathology is still unclear. The micro
RNAs (miRNAs), of host or viral origin, interfere with virus replication and host environment …

Hepatitis e virus persistence and/or replication in the peripheral blood mononuclear cells of acute HEV-infected patients

IM Sayed, ZA Abd Elhameed… - Frontiers in …, 2021 - frontiersin.org
Background Hepatitis E virus (HEV) causes about 14 million infections with 300,000 deaths
and 5,200 stillbirths worldwide annually. Extrahepatic manifestations are reported with HEV …

Computational identification of hepatitis E virus‐encoded microRNAs and their targets in human

V Baruah, S Bose - Journal of Medical Virology, 2019 - Wiley Online Library
Abstract microRNAs (miRNAs) are small, noncoding RNAs which regulate eukaryotic gene
expression via RNA interference pathway. Recently, miRNAs have been identified in a …

Identification of miR-221 and-222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells

Y Cheng, L Du, Q Shi, H Jiao, X Zhang, Y Hao, H Rong… - Virus Genes, 2013 - Springer
Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute
viral hepatitis worldwide, which is a major public health challenge. A better understanding of …

[PDF][PDF] The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response

W Wang, Y Wang, C Qu, S Wang, J Zhou, W Cao… - …, 2018 - Wiley Online Library
The outcomes of hepatitis E virus (HEV) infection are diverse, ranging from asymptomatic
carrier, self‐limiting acute infection, and fulminant hepatitis to persistent infection. This is …

Hepatitis E virus (HEV) ORF2 antigen levels differentiate between acute and chronic HEV infection

P Behrendt, B Bremer, D Todt… - The Journal of …, 2016 - academic.oup.com
Abstract Background. Hepatitis E virus (HEV) genotype 3 infections are frequent in Europe
and North America, with acute and chronic courses described in the literature. HEV RNA …