The pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease, is a
subject of increasing interest. Loss-of-function mutations in nucleotide‑binding …

Inflammatory bowel disease (IBD) consists of Crohn's disease (CD) and ulcerative colitis
(UC). It is thought to be caused by genetic, abnormal immune response of the intestinal …

Objective We aimed to investigate the role of the phosphatidylinositol 3‐kinase/protein
kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway and its …

Although Toll-like receptor 4 (TLR4)-and nucleotide-binding oligomerization domain 2
(NOD2)-mediated signaling mechanisms have been extensively studied individually, the …

Background: Crohn's disease is an autoimmune inflammatory disorder of the gastrointestinal
tract and is characterized clinically by dysregulation of both pro-inflammatory and anti …

Despite considerable progress elucidating the cellular and molecular events associated with
chronic inflammatory bowel diseases (IBD), the etiology of Crohn's disease (CD) and …

K63 polyubiquitin chains spatially and temporally link innate immune signaling effectors
such that cytokine release can be coordinated. Crohn's disease is a prototypical …

Results of recent genetic and immunologic studies have brought to the forefront several
biologic pathways that allow for a better understanding of the mechanisms of tissue …

Inflammatory bowel diseases (IBD)—Crohn's disease and ulcerative colitis—are relapsing
chronic inflammatory disorders which involve genetic, immunological, and environmental …

The Crohn's-disease-susceptibility protein, NOD2, coordinates signaling responses upon
intracellular exposure to bacteria [1–6]. Although NOD2 is known to activate NFκB, little is …