Interacting symbionts and immunity in the amphibian skin mucosome predict disease risk and probiotic effectiveness
DC Woodhams, H Brandt, S Baumgartner, J Kielgast… - PloS one, 2014 - journals.plos.org
Pathogenesis is strongly dependent on microbial context, but development of probiotic
therapies has neglected the impact of ecological interactions. Dynamics among microbial …
therapies has neglected the impact of ecological interactions. Dynamics among microbial …
Stability of microbiota facilitated by host immune regulation: informing probiotic strategies to manage amphibian disease
Microbial communities can augment host immune responses and probiotic therapies are
under development to prevent or treat diseases of humans, crops, livestock, and wildlife …
under development to prevent or treat diseases of humans, crops, livestock, and wildlife …
Harnessing the microbiome to prevent fungal infections: lessons from amphibians
All multicellular organisms are host to microbial symbionts that constitute the microbiome
and can have significant impacts on the host, including altering development, behavior, and …
and can have significant impacts on the host, including altering development, behavior, and …
Probiotic treatment restores protection against lethal fungal infection lost during amphibian captivity
JG Kueneman, DC Woodhams… - … of the Royal …, 2016 - royalsocietypublishing.org
Host-associated microbiomes perform many beneficial functions including resisting
pathogens and training the immune system. Here, we show that amphibians developing in …
pathogens and training the immune system. Here, we show that amphibians developing in …
Managing amphibian disease with skin microbiota
The contribution of emerging amphibian diseases to the sixth mass extinction is driving
innovative wildlife management strategies, including the use of probiotics. Bioaugmentation …
innovative wildlife management strategies, including the use of probiotics. Bioaugmentation …
Fight fungi with fungi: antifungal properties of the amphibian mycobiome
PJ Kearns, S Fischer… - Frontiers in …, 2017 - frontiersin.org
Emerging infectious diseases caused by fungal taxa are increasing and are placing a
substantial burden on economies and ecosystems worldwide. Of the emerging fungal …
substantial burden on economies and ecosystems worldwide. Of the emerging fungal …
The adaptive microbiome hypothesis and immune interactions in amphibian mucus
DC Woodhams, J McCartney, JB Walke… - Developmental & …, 2023 - Elsevier
The microbiome is known to provide benefits to hosts, including extension of immune
function. Amphibians are a powerful immunological model for examining mucosal defenses …
function. Amphibians are a powerful immunological model for examining mucosal defenses …
Context-dependent symbioses and their potential roles in wildlife diseases
It is well known in ecology, evolution and medicine that both the nature (commensal,
parasitic and mutualistic) and outcome (symbiont fitness, survival) of symbiotic interactions …
parasitic and mutualistic) and outcome (symbiont fitness, survival) of symbiotic interactions …
Addition of antifungal skin bacteria to salamanders ameliorates the effects of chytridiomycosis
Chytridiomycosis, caused by the skin fungus Batrachochytrium dendrobatidis (Bd), has
caused population declines of many amphibians in remote protected habitats. Progress has …
caused population declines of many amphibians in remote protected habitats. Progress has …
The amphibian skin microbiome and its protective role against chytridiomycosis
Here we review the knowledge about skin microbiomes in amphibians accumulated over the
last two decades and the evidence regarding the protective role of skin bacteria. Amphibians …
last two decades and the evidence regarding the protective role of skin bacteria. Amphibians …