Interacting symbionts and immunity in the amphibian skin mucosome predict disease risk and probiotic effectiveness

DC Woodhams, H Brandt, S Baumgartner, J Kielgast… - PloS one, 2014 - journals.plos.org
Pathogenesis is strongly dependent on microbial context, but development of probiotic
therapies has neglected the impact of ecological interactions. Dynamics among microbial …

Stability of microbiota facilitated by host immune regulation: informing probiotic strategies to manage amphibian disease

D Küng, L Bigler, LR Davis, B Gratwicke, E Griffith… - PLoS …, 2014 - journals.plos.org
Microbial communities can augment host immune responses and probiotic therapies are
under development to prevent or treat diseases of humans, crops, livestock, and wildlife …

Harnessing the microbiome to prevent fungal infections: lessons from amphibians

JB Walke, LK Belden - PLoS pathogens, 2016 - journals.plos.org
All multicellular organisms are host to microbial symbionts that constitute the microbiome
and can have significant impacts on the host, including altering development, behavior, and …

Probiotic treatment restores protection against lethal fungal infection lost during amphibian captivity

JG Kueneman, DC Woodhams… - … of the Royal …, 2016 - royalsocietypublishing.org
Host-associated microbiomes perform many beneficial functions including resisting
pathogens and training the immune system. Here, we show that amphibians developing in …

Managing amphibian disease with skin microbiota

DC Woodhams, M Bletz, J Kueneman… - Trends in microbiology, 2016 - cell.com
The contribution of emerging amphibian diseases to the sixth mass extinction is driving
innovative wildlife management strategies, including the use of probiotics. Bioaugmentation …

Fight fungi with fungi: antifungal properties of the amphibian mycobiome

PJ Kearns, S Fischer… - Frontiers in …, 2017 - frontiersin.org
Emerging infectious diseases caused by fungal taxa are increasing and are placing a
substantial burden on economies and ecosystems worldwide. Of the emerging fungal …

The adaptive microbiome hypothesis and immune interactions in amphibian mucus

DC Woodhams, J McCartney, JB Walke… - Developmental & …, 2023 - Elsevier
The microbiome is known to provide benefits to hosts, including extension of immune
function. Amphibians are a powerful immunological model for examining mucosal defenses …

Context-dependent symbioses and their potential roles in wildlife diseases

JH Daskin, RA Alford - … of the Royal Society B: Biological …, 2012 - royalsocietypublishing.org
It is well known in ecology, evolution and medicine that both the nature (commensal,
parasitic and mutualistic) and outcome (symbiont fitness, survival) of symbiotic interactions …

Addition of antifungal skin bacteria to salamanders ameliorates the effects of chytridiomycosis

RN Harris, A Lauer, MA Simon, JL Banning… - Diseases of aquatic …, 2009 - int-res.com
Chytridiomycosis, caused by the skin fungus Batrachochytrium dendrobatidis (Bd), has
caused population declines of many amphibians in remote protected habitats. Progress has …

The amphibian skin microbiome and its protective role against chytridiomycosis

EA Rebollar, E Martínez-Ugalde, AH Orta - Herpetologica, 2020 - meridian.allenpress.com
Here we review the knowledge about skin microbiomes in amphibians accumulated over the
last two decades and the evidence regarding the protective role of skin bacteria. Amphibians …