Migraine: disease characterisation, biomarkers, and precision medicine

M Ashina, GM Terwindt, MAM Al-Karagholi, I De Boer… - The Lancet, 2021 - thelancet.com
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Biomarkers associated with migraine and their potential role in migraine management

P Durham, S Papapetropoulos - … The Journal of Head and Face …, 2013 - Wiley Online Library
Objective The focus of this review is to review potential diagnostic and therapeutic
biomarkers associated with migraine. Background Migraine headache is a common disease …

Migraine pathophysiology: lessons from mouse models and human genetics

MD Ferrari, RR Klever, GM Terwindt, C Ayata… - The Lancet …, 2015 - thelancet.com
Migraine is a common, disabling, and undertreated episodic brain disorder that is more
common in women than in men. Unbiased genome-wide association studies have identified …

The pathophysiology of migraine: implications for clinical management

A Charles - The Lancet Neurology, 2018 - thelancet.com
The understanding of migraine pathophysiology is advancing rapidly. Improved
characterisation and diagnosis of its clinical features have led to the view of migraine as a …

[HTML][HTML] Advances in genetics of migraine

HG Sutherland, CL Albury, LR Griffiths - The journal of headache and pain, 2019 - Springer
Background Migraine is a complex neurovascular disorder with a strong genetic component.
There are rare monogenic forms of migraine, as well as more common polygenic forms; …

What is the actual prevalence of migraine?

WZ Yeh, L Blizzard, BV Taylor - Brain and behavior, 2018 - Wiley Online Library
Objectives Population prevalence studies of migraine report prevalence rates of between
2.6 and 21.7%, with an average of~ 12%. However, migraine prevalence among …

Genetics of migraine

V Anttila, M Wessman, M Kallela, A Palotie - Handbook of clinical neurology, 2018 - Elsevier
Genetics of migraine has recently undergone a major shift, moving in the space of a few
years from having only a few known genes for rare Mendelian forms to 47 known common …

[HTML][HTML] Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

H Hautakangas, BS Winsvold, SE Ruotsalainen… - Nature …, 2022 - nature.com
Migraine affects over a billion individuals worldwide but its genetic underpinning remains
largely unknown. Here, we performed a genome-wide association study of 102,084 …

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

P Gormley, V Anttila, BS Winsvold, P Palta, T Esko… - Nature …, 2016 - nature.com
Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Exploring the hereditary nature of migraine

C Bron, HG Sutherland, LR Griffiths - Neuropsychiatric Disease and …, 2021 - Taylor & Francis
Migraine is a common neurological disorder which affects 15–20% of the population; it has a
high socioeconomic impact through treatment and loss of productivity. Current forms of …