Background Cholestasis, as a main manifestation, induces liver injury during sepsis. The
farnesoid X receptor (FXR) plays an important role in regulating bile acid homeostasis …

The farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays important
roles in regulating bile acid homeostasis. The aim of the present study was to investigate the …

It is increasingly recognized that farnesoid X receptor (FXR) has anti-inflammatory and
antioxidant activities. The present study investigated the effects of obeticholic acid (OCA), a …

Introduction The farnesoid X receptor (FXR) is abundantly expressed in the ileum, where it
exerts an enteroprotective role as a key regulator of intestinal innate immunity and …

Cholestasis is a clinical syndrome with systemic and intrahepatic accumulation of excessive
toxic bile acids that ultimately cause hepatobiliary injury. Recently obeticholic acid (OCA) …

Background Cholestasis is a clinical syndrome with high incidence and few effective
treatments. Oleanolic acid (OA) is a triterpenoid compound with anti-cholestatic effects …

Objective Obeticholic acid (OCA) has been proved to play potential therapeutic effect on
nonalcoholic steatohepatitis (NASH). Up to now, the study of OCA on NLRP3 inflammasome …

Cholestasis is a pathophysiologic syndrome with limited therapeutic options.
Tauroursodeoxycholic acid (TUDCA) has been employed to treat hepatobiliary disorders …

The farnesoid-X-receptor (FXR) is validated target in the cholestatic disorders treatment.
Obeticholic acid (OCA), the first in class of FXR agonist approved for clinical use, causes …

The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid
homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease …