The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules
Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …
they display vast biological activities. Recent efforts concerning the preparation of oxindole …
Engaging isatins in multicomponent reactions (MCRs)–easy access to structural diversity
Multicomponent reactions (MCRs) are a valuable tool in diversity‐oriented synthesis. Its
application to privileged structures is gaining relevance in the fields of organic and …
application to privileged structures is gaining relevance in the fields of organic and …
Recent advances in the application of indoles in multicomponent reactions
Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds
and are frequently used in the synthesis of various organic compounds. Indole based …
and are frequently used in the synthesis of various organic compounds. Indole based …
Propagative isatin in organic synthesis of spirooxindoles through catalysis
Abstract Oxindole (indoline-2, 3-dione) has been utilized to a great extent in heterocyclic
scaffold syntheses as a futuristic medication and is considered a prominent building block …
scaffold syntheses as a futuristic medication and is considered a prominent building block …
An insight into the advanced synthetic recipes to access ubiquitous indole heterocycles
Indoles are amongst the most essential class of heteroaromatics in organic chemistry, being
commonly found in biologically active natural products. Indole and its derivatives have …
commonly found in biologically active natural products. Indole and its derivatives have …
Recent advances in diversity oriented synthesis through isatin‐based multicomponent reactions
Y Liu, H Wang, J Wan - Asian Journal of Organic Chemistry, 2013 - Wiley Online Library
Isatins are well‐known carbonyl electrophiles which allow a vast number of reactions
initiated by nucleophilic attack on the C3 carbonyl group when used as starting materials …
initiated by nucleophilic attack on the C3 carbonyl group when used as starting materials …
Lambert salt-initiated development of Friedel–crafts reaction on isatin to access distinct derivatives of oxindoles
Herein, a mild metal-free and efficacious route for the synthesis of biologically important 3-
aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a …
aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a …
[HTML][HTML] Synthesis of indole derivatives as prevalent moieties present in selected alkaloids
MM Heravi, Z Amiri, K Kafshdarzadeh, V Zadsirjan - RSC advances, 2021 - pubs.rsc.org
Indoles are a significant heterocyclic system in natural products and drugs. They are
important types of molecules and natural products and play a main role in cell biology. The …
important types of molecules and natural products and play a main role in cell biology. The …
Recent advances in indoline synthesis
Indoline is an important structural motif present in several biologically active compounds
from both natural and synthetic origins. The occurrence of this heterocyclic unity in these …
from both natural and synthetic origins. The occurrence of this heterocyclic unity in these …
[HTML][HTML] Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)
A Dhiman, R Sharma, RK Singh - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …