Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. Many patients with cancer experience reduced life expectancy and …

Health is not defined by the absence of disease or suffering, but by response to a series of
life events that can markedly alter the quality and quantity of life. Patients with cancer …

Purpose In this paper, we provide an overview of a life history theory and how it applies to
cancer evolution. Recent Findings We review the literature on trade-offs in tumors, focusing …

The goal of all medical activity is to preserve health in fit people, and to restore the sick into a
state of complete physical, mental and social wellbeing. In an effort to determine whether we …

New therapeutic approaches can produce promising results even in severely ill cancer
patients. But they also pose new challenges with respect to prognostication, as patients who …

Over the past decades, early diagnosis, new drugs and more personalised multi-modality
treatment have led to impressive increases in survival rates of patients with cancer. This …

The growing population of individuals living long term following a cancer diagnosis has led
to a rapid acceleration in the pace of survivorship research. Much is already known about …

Over the last decade, clinicians have accepted that while survival and disease-free survival
are critical factors for cancer patients, overall quality-of-life is fundamental. This review …

Despite improvements in cancer therapies, cancer is the leading cause of death worldwide.
Many patients experience severe, unnecessary symptoms during treatment as well as at the …

Traditionally, clinical cancer investigation has focused on endpoints such as response,
disease control, and survival. This approach has been instrumental in identifying effective …