Patients with atrial fibrillation (AF) on long-term direct oral anticoagulants (DOACs) may be
at higher risk of bleeding because of higher anti-Xa or anti-IIa levels. However, there is no …

Background Patients with atrial fibrillation (AF) who are on long-term direct oral
anticoagulants (DOAC) with low anti-Xa or anti-IIa levels may be at higher risk of recurrent …

Essentials• Currently, DOACs are given at fixed doses and do not require laboratory
monitoring.• Direct oral anticoagulant‐specific measurements were performed at trough and …

Essentials• Direct oral anticoagulants (DOACs) do not require laboratory monitoring
currently.• DOAC specific measurements were performed at trough in patients with atrial …

Although effective and safe, treatment with direct oral anticoagulants (DOAC) in atrial
fibrillation (AF) is still associated with thrombotic complications. Whether the measurement of …

Background Direct-acting oral anticoagulants (DOACs) are widely prescribed for stroke
prevention in patients with atrial fibrillation (AF). An important advantage of DOACs is that …

Treatment with direct oral anticoagulants (DOAC) in atrial fibrillation (AF) patients is effective
and safe. However, bleeding complications still occur. Whether the measurement of DOAC …

Background Atrial fibrillation (AF) ablation with minimally interrupted direct oral
anticoagulants (DOACs) predominates, possibly raising concern about their remaining …

Introduction Direct oral anticoagulant (DOAC) intra-and inter-individual variability was
previously reported, but its magnitude is still considered negligible for patient management …

Data are limited on the effects of drug interactions on direct-acting oral anticoagulant
(DOAC) levels. We evaluated the effects of the use of interacting drugs on DOAC levels in …