[HTML][HTML] Multiple biological functions of Twist1 in various cancers

Z Zhao, MA Rahman, ZG Chen, DM Shin - Oncotarget, 2017 - ncbi.nlm.nih.gov
Twist1 is a well-known regulator of transcription during embryonic organogenesis in many
species. In humans, Twist1 malfunction was first linked to Saethre-Chotzen syndrome and …

The role of TWIST1 in epithelial-mesenchymal transition and cancers

QQ Zhu, C Ma, Q Wang, Y Song, T Lv - Tumor Biology, 2016 - Springer
TWIST1 is a basic helix-loop-helix (bHLH) transcription factor which plays essential and
pivotal roles in multiple stages of embryonic development, and significantly contributes to …

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

Q Qin, Y Xu, T He, C Qin, J Xu - Cell research, 2012 - nature.com
This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

[HTML][HTML] TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis

SV Nuti, G Mor, P Li, G Yin - Oncotarget, 2014 - ncbi.nlm.nih.gov
The transcription factor TWIST1 is a highly evolutionally conserved basic Helix-Loop-Helix
(bHLH) transcription factor that functions as a master regulator of gastrulation and …

Different levels of Twist1 regulate skin tumor initiation, stemness, and progression

B Beck, G Lapouge, S Rorive, B Drogat… - Cell stem cell, 2015 - cell.com
Twist1 promotes epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and
cancer stem cell (CSC) properties. However, it remains unclear whether Twist1 is also …

[HTML][HTML] Unraveling the TWIST between EMT and cancer stemness

HY Jung, J Yang - Cell Stem Cell, 2015 - cell.com
Twist1 has a well-established role in inducing Epithelial-Mesenchymal Transition (EMT) to
promote tumor invasion and metastasis and can also inhibit apoptosis and confer stemness …

Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24

AY Liu, Y Cai, Y Mao, Y Lin, H Zheng, T Wu… - …, 2014 - academic.oup.com
Twist2 is a highly conserved basic helix-loop-helix transcription factor that plays a critical
role in embryogenesis. Recent evidence has revealed that aberrant Twist2 expression …

Twist: a molecular target in cancer therapeutics

MA Khan, H Chen, D Zhang, J Fu - Tumor Biology, 2013 - Springer
Twist, the basic helix-loop-helix transcription factor, is involved in the process of epithelial to
mesenchymal transitions (EMTs), which play an essential role in cancer metastasis …

Twist1 induces CCL2 and recruits macrophages to promote angiogenesis

JM Low-Marchelli, VC Ardi, EA Vizcarra, N Van Rooijen… - Cancer research, 2013 - AACR
The transcription factor Twist1 induces epithelial–mesenchymal transition and extracellular
matrix degradation to promote tumor metastasis. Although Twist1 also plays a role in …

Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival

A Wushou, J Hou, YJ Zhao, ZM Shao - International journal of molecular …, 2014 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) facilitates tumor metastasis. Twist is a basic helix-
loop-helix protein that modulates many target genes through E-box-responsive elements …