Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

The maintenance of the proteome is essential to preserve cell functionality and the ability to
respond and adapt to the changing environment. This is regulated by the proteostasis …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. Alterations in these fine-tuned mechanisms underlie the …

Genetic and environmental factors responsible for numerous neurodegenerative diseases
vary between disorders, yet age remains a universal risk factor. Age-associated decline in …

Aging cells accumulate damaged and misfolded proteins through a functional decline in
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

Damaged and misfolded proteins accumulate during the aging process, impairing cell
function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) …

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …

The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for
brain processes, including learning and memory. Increasing evidence indicates that …