Acceleration of microglial clearance function by small TREM2-activating anionic disaccharides

V Nunes de Paiva - 2014 - bonndoc.ulb.uni-bonn.de
Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor,
which is expressed on myeloid cells, like microglia inside the central nervous system …

[HTML][HTML] TREM2 ectodomain and its soluble form in Alzheimer's disease

J Yang, Z Fu, X Zhang, M Xiong, L Meng… - Journal of …, 2020 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed
on the surface of microglia. It mediates multiple pathophysiological processes in various …

[HTML][HTML] TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease

Y Li, H Xu, H Wang, K Yang, J Luan, S Wang - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …

Regulation of triggering receptor expressed on myeloid cells-2 (TREM2) expression in microglia

S Wu - 2012 - era.ed.ac.uk
Background: Activation of microglia is a feature of several neurodegenerative diseases.
TREM2 is an immune receptor expressed by macrophages and microglia, which negatively …

Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation-neglected multidimensional regulation of microglia

X Zhang, X Chen, L Zhang, Y Sun, Y Liang, H Li… - Neurochemistry …, 2023 - Elsevier
Neuroinflammation is an inflammatory cascade involved in various neurological disorders,
including Alzheimer's disease, multiple sclerosis, and other relevant diseases. The …

Key role of TREM-2 on microglia in cuprizone-induced demyelination model

C Cantoni, K Otero, B Bollman, A Cross… - Journal of …, 2014 - jni-journal.com
Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor
expressed on microglia and macrophages. Engagement of TREM-2 on these cells has been …

The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke

W Ma, S Wang, Q Wu, X Zhou, S Chu… - International …, 2022 - Elsevier
Microglia are the earliest activated and the longest lasting immune cells after stroke, and
they participate in almost all the pathological reactions after stroke. However, their regulatory …

sTREM2 affects cytokine expression profiles in THP‐1 cell model.

R Arsenault, Q Li, W Zhang - Alzheimer's & Dementia, 2022 - Wiley Online Library
Background TREM2 is an innate immune receptor expressed on myeloid cells such as
microglia and macrophages and is involved in several crucial cellular response pathways …

Divergent neuroinflammatory regulation of microglial TREM expression and involvement of NF-κB

R Owens, K Grabert, CL Davies, A Alfieri… - Frontiers in cellular …, 2017 - frontiersin.org
The triggering receptor expressed on myeloid cells (TREM) family of proteins are cell
surface receptors with important roles in regulation of myeloid cell inflammatory activity. In …

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

L Piccio, C Buonsanti, M Cella, I Tassi, RE Schmidt… - Brain, 2008 - academic.oup.com
Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor
expressed by microglia and macrophages. Engagement of TREM-2 on these cells has been …