Neural Mechanisms

D Hering, G Seravalle, G Grassi… - Hypertension and Heart …, 2019 - Springer
The last four decades of extensive investigations have revealed that sympathetic nervous
system plays a critical pathogenic role in blood pressure elevation and sustained …

Sympathetic Activity in Hypertension and Heart Failure

D Hering, G Seravalle, G Grassi… - Hypertension and Heart …, 2024 - Springer
The sympathetic nervous system (SNS) is a major regulatory component of the
cardiovascular (CV) system affecting short-and long-term blood pressure regulation in the …

Role of the sympathetic nervous system in hypertension and hypertension-related cardiovascular disease

G Seravalle, G Mancia, G Grassi - High Blood Pressure & Cardiovascular …, 2014 - Springer
A number of cardiovascular disease have been shown to be characterized by a marked
increase in sympathetic drive to the heart and the peripheral circulation. This is the case for …

The sympathetic nervous system alterations in human hypertension

G Grassi, A Mark, M Esler - Circulation research, 2015 - Am Heart Assoc
Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

Sympathetic nervous system contributions to hypertension: updates and therapeutic relevance

LJ DeLalio, AF Sved, SD Stocker - Canadian Journal of Cardiology, 2020 - Elsevier
The sympathetic nervous system plays a pivotal role in the long-term regulation of arterial
blood pressure through the ability of the central nervous system to integrate neurohumoral …

[PDF][PDF] Sympathetic activation in cardiovascular and renal disease

G Grassi, F Arenare, F Pieruzzi, G Brambilla… - J Nephrol, 2009 - researchgate.net
Given the importance of adrenergic neural functioning in cardiovascular control, the
hypothesis that an elevation in sympathetic drive represents a key pathophysiological …

The sympathetic nervous system and blood pressure in humans: implications for hypertension

JP Fisher, JFR Paton - Journal of human hypertension, 2012 - nature.com
A neurogenic component to primary hypertension (hypertension) is now well established.
Along with raised vasomotor tone and increased cardiac output, the chronic activation of the …

The sympathetic nervous system in hypertension: roadmap update of a long journey

G Grassi - American Journal of Hypertension, 2021 - academic.oup.com
The present paper will provide an update on the role of sympathetic neural factors in the
development and progression of essential hypertension by reviewing data collected in the …

CNS pathways contributing to sympathetic hyperactivity and hypertension

FHH Leenen - 2013 - Taylor & Francis
Chronic sympathetic hyperactivity is present in the majority of patients with hypertension,
and contributes to cardiovascular morbidity and mortality through a number of effects. Its role …

The sympathetic nervous system and new nonpharmacologic approaches to treating hypertension: a focus on renal denervation

G Grassi, G Seravalle, G Brambilla, G Mancia - Canadian Journal of …, 2012 - Elsevier
The sympathetic nervous system is activated in a variety of cardiovascular and metabolic
diseases. This is particularly the case for essential hypertension, in which various indices of …