The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV) …

Transmission of HIV-1 results in the establishment of a new infection, typically starting from a
single virus particle. That virion replicates to generate viremia and persistent infection in all …

HIV-1 is completely dependent upon the Env protein to enter cells. The virus typically
replicates in activated CD4+ T cells due to viral entry requirements for the CCR5 coreceptor …

Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The
understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral …

Interactions between the viral envelope glycoprotein gp120 and the cell surface receptor
CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host …

Human immunodeficiency virus has evolved several redundant mechanisms to remove its
receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins …

The human AIDS viruses–HIV-1 and HIV-2–impose major burdens on the health and
economic status of many developing countries. Surveys of other animal species have …

SUMMARY HIV‐1 and HIV‐2 share many similarities including their basic gene
arrangement, modes of transmission, intracellular replication pathways and clinical …

The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …