Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Context With the aging of the population and projected increase in osteoporotic fractures
coupled with the declining use of osteoporosis medications, there is a compelling need for …

Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Age‐related bone loss is in large part the consequence of senescence mechanisms that
impact bone cell number and function. In recent years, progress has been made in the …

The human skeleton serves several functions for the body: support, locomotion, protection of
vital organs, and housing of bone marrow. Bone remodeling is the result of the interactions …

Age-related chronic diseases are an enormous burden to modern societies worldwide.
Among these, osteoporosis, a condition that predisposes individuals to an increased risk of …

Human aging is associated with bone loss leading to bone fragility and increased risk of
fractures. The cellular and molecular causes of age‐related bone loss are current intensive …

Cellular senescence is a fundamental mechanism by which cells remain metabolically
active yet cease dividing and undergo distinct phenotypic alterations, including upregulation …

Advancing age and loss of bone mass and strength are closely linked. Elevated osteoblast
and osteocyte apoptosis and decreased osteoblast number characterize the age-related …

Cellular senescence refers to a process induced by various types of stress that causes
irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …