Converging evidence implicates redox dysregulation as a pathological mechanism driving
the emergence of psychosis. Increased oxidative damage and decreased capacity of …

In schizophrenia, a developmental redox dysregulation constitutes one 'hub'on which
converge genetic impairments of glutathione synthesis and environmental vulnerability …

Significance: Schizophrenia (SZ) and bipolar disorder (BD) are classified as two distinct
diseases. However, accumulating evidence shows that both disorders share genetic …

Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia.
In particular, oxidative damage to lipids, proteins, and DNA as observed in schizophrenia is …

Abnormal redox homeostasis and oxidative stress have been proposed to play a role in the
etiology of several neuropsychiatric spectrum disorders. Emerging interest has recently …

A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

Redox biology and immune signaling play major roles in the body, including in brain
function. A rapidly growing literature also suggests that redox and immune abnormalities are …

Over a century, a wide-ranging variety of pathophysiological models and causal hypotheses
have been conceptualized for schizophrenia. One among these is the role for free radical …

Because increasing evidence point to the convergence of environmental and genetic risk
factors to drive redox dysregulation in schizophrenia, we aim to clarify whether the metabolic …

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …