We examine five quantitative models of the cell-cycle and cell-size control in Escherichia coli
and Bacillus subtilis that have been proposed over the last decade to explain single-cell …

In physics, it is customary to represent the fluctuations of a stochastic system at steady state
in terms of linear response to small random perturbations. Previous work has shown that the …

How growth, the cell cycle, and cell size are coordinated is a fundamental question in
biology. Recently, we and others have shown that bacterial cells grow by a constant added …

Small, fast-growing bacteria make ideal subjects for genetic and quantitative analysis alike.
Long the darling of theoreticians, efforts to understand the relationship between cell growth …

Recent studies taking advantage of automated single‐cell time‐lapse analysis have
reignited interest in the bacterial cell cycle. Several studies have highlighted alternative …

Experiments on steady-state bacterial cultures have uncovered several quantitative
regularities at the system level. These include, first, the exponential growth of cell size with …

Organisms across all domains of life regulate the size of their cells. However, the means by
which this is done is poorly understood. We study two abstracted “molecular” models for size …

The coordination of cell growth and division is a long-standing problem in biology. Focusing
on Escherichia coli in steady growth, we quantify cell division control using a stochastic …

The inherent stochasticity of molecular reactions prevents us from predicting the exact state
of single-cells in a population. However, when a population grows at steady-state, the …

Isogenic E. coli cells growing in a constant environment display significant variability in
growth rates, division sizes, and generation times. The guiding principle appears to be that …