Inflammatory Bowel Disease (IBD) represents a group of idiopathic disorders characterized
by chronic or recurring inflammation of the gastrointestinal tract. While the exact etiology of …

Mitochondria serve numerous critical cellular functions, rapidly responding to extracellular
stimuli and cellular demands while dynamically communicating with other organelles …

Background & Aims Mitochondria exist in a constantly remodelling network, and excessive
fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric …

The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

The mitochondrion is also a major site for maintaining redox homeostasis between reactive
oxygen species (ROS) generation and scavenging. The quantity, quality, and functional …

Background Systemic low-grade inflammation observed in diet-induced obesity has been
associated with dysbiosis and disturbance of intestinal homeostasis. This latter relies on an …

Mitochondria has emerged as a critical ruler of metabolic reprogramming in immune
responses and inflammation. In the context of colitogenic T cells and IBD, there has been …

Inflammatory Bowel Disease (IBD) is characterized by a loss of intestinal barrier function
caused by an aberrant interaction between the immune response and the gut microbiota. In …

The intestinal epithelium represents the most regenerative tissue in the human body, located
in proximity to the dense and functionally diverse microbial milieu of the microbiome …