Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

During the past 5 years, it has become increasingly apparent that deregulated
transcriptional control is a root cause of hematologic malignancy. Chromosomal …

The human genome is epigenetically organized through a series of modifications to the
histone proteins that interact with the DNA. In cancer, many of the proteins that regulate …

Histone deacetylases (HDAC s) critically regulate gene expression by determining the
acetylation status of histones. Studies have increasingly focused on the activities of HDAC s …

Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating
gene expression, and behave as oncogenes in several cancer types, spurring the …

Histone deacetylases (HDACs) are master regulators of chromatin remodeling, acting as
epigenetic regulators of gene expression. In the last decade, inhibition of HDACs has …

Histone deacetylase (HDAC) inhibitors are emerging as promising anticancer drugs.
Because aberrant activity and expression of HDACs have been implicated in various cancer …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Histone deacetylases (HDACs) are globally implicated in the growth and differentiation of
mammalian cells; however, relatively little is known about their specific roles in …

Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of
nonhistone transcription regulatory proteins, thus modulating the expression of genes …