Quantifying clinical relevance in the treatment of schizophrenia

CU Correll, T Kishimoto, J Nielsen, JM Kane - Clinical therapeutics, 2011 - Elsevier
BACKGROUND: To optimize the management of patients with schizophrenia, quantification
of treatment effects is crucial. While in research studies, the use of quantitative assessments …

Tools for measuring clinical effectiveness

D Naber, A Vita - European neuropsychopharmacology, 2004 - Elsevier
Efficacy studies fail to consider the multiple aspects of schizophrenia that determine the
overall clinical effectiveness of treatment. We address this shortcoming by proposing …

Towards a framework for treatment effectiveness in schizophrenia

G Juckel, A de Bartolomeis, P Gorwood… - Neuropsychiatric …, 2014 - Taylor & Francis
Introduction Prompt administration of antipsychotic treatment that is adhered to is essential
for the optimal treatment of schizophrenia. Many patients have benefited from the advent of …

Defining therapeutic benefit for people with schizophrenia: focus on negative symptoms

NR Schooler, RW Buchanan, T Laughren… - Schizophrenia …, 2015 - Elsevier
Schizophrenia is a complex, heterogeneous, multidimensional disorder within which
negative symptoms are a significant and disabling feature. Whilst there is no established …

An instrument for measurement of outcomes of care for schizophrenia: issues in development and implementation

BJ Cuffel, EP Fischer, RR Owen Jr… - Evaluation & the …, 1997 - journals.sagepub.com
To advance effectiveness research in mental health, we need common, standardized,
validated instruments that can be used easily in routine practice settings. The Schizophrenia …

[PDF][PDF] Balancing therapeutic safety and efficacy to improve clinical and economic outcomes in schizophrenia: a clinical overview

DC Javitt - Am J Manag Care, 2014 - ajmc.s3.amazonaws.com
Affecting up to 1% of the global population, schizophrenia is a chronic, disabling psychiatric
disorder that has profound effects on patients, families, and caretakers due to its tremendous …

Dissecting the heterogeneity of treatment response in first-episode schizophrenia

AK Malhotra - Schizophrenia bulletin, 2015 - academic.oup.com
Abstract The Mental Health Centers for Intervention Development and Applied Research
(CIDAR) program prioritized research to provide an evidence base for biomarker …

Novel rating scales for schizophrenia—targeted inventory on problems in schizophrenia (TIP-Sz) and functional assessment for comprehensive treatment of …

T Suzuki, H Uchida, K Nomura, H Takeuchi… - Schizophrenia …, 2008 - Elsevier
OBJECTIVE: Many rating scales have been in use to evaluate various symptomatic
domains, and eventually there are too many scales to be selected and widely utilized in …

Defining and measuring clinical effectiveness in the treatment of schizophrenia

HA Nasrallah, SD Targum, R Tandon… - Psychiatric …, 2005 - Am Psychiatric Assoc
OBJECTIVES: Expectations in treating schizophrenia are expanding beyond just controlling
psychotic symptoms to include functional recovery. This report describes an approach to …

Evolution of outcome measures in schizophrenia

T Burns - The British Journal of Psychiatry, 2007 - cambridge.org
Outcome has been a key concern in schizophrenia since Kraepelin first identified the
disorder. The outcomes that researchers and clinicians use and value in their work with it …