Promising heterocycle-based scaffolds in recent (2019–2021) anti-Alzheimer's drug design and discovery

A Dorababu - European Journal of Pharmacology, 2022 - Elsevier
Alzheimer's disease (AD) is one of the neurodegenerative diseases that led to morbidity and
mortality world-wide. It is a complex disease whose etiology is not completely known that …

Heterocyclic scaffolds for the treatment of Alzheimer's disease

A Martorana, V Giacalone, R Bonsignore… - Current …, 2016 - ingentaconnect.com
Background: The treatment and diagnosis of Alzheimer's Disease (AD) are two of the most
urgent goals for research around the world. The cognitive decline is generally associated …

Advances in the discovery of heterocyclic-based drugs against Alzheimer's disease

JD Sánchez, AR Alcántara, JF González… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …

Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships

M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …

Current progresses of novel natural products and their derivatives/analogs as anti-Alzheimer candidates: an update

L Fang, S Gou, X Fang, L Cheng… - Mini reviews in …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is one of the most threatening diseases affecting the aged with
high incidence. Though AD has been defined for more than 100 years, it is still incurable …

Alzheimer's disease: emerging trends in small molecule therapies

T Mohamed, P PN Rao - Current medicinal chemistry, 2011 - ingentaconnect.com
Alzheimer's disease (AD) is a highly complex and rapidly progressive neurodegenerative
disorder characterized by the systemic collapse of cognitive function and formation of dense …

Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer's disease therapy

A Hiremathad, L Piemontese - Neural regeneration research, 2017 - journals.lww.com
Nowadays, Alzheimer's disease (AD) is widely recognized as a real social problem. In fact,
only five drugs are FDA approved for the therapy of this widespread neurodegenerative …

Sustainable drug discovery of multi-target-directed ligands for Alzheimer's disease

M Rossi, M Freschi… - Journal of medicinal …, 2021 - ACS Publications
The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …

Critical evaluation of current Alzheimer's drug discovery (2018–19) & futuristic Alzheimer drug model approach

A Dorababu - Bioorganic Chemistry, 2019 - Elsevier
Abstract Alzheimer′ s disease (AD), a neurodegenerative disease responsible for death of
millions of people worldwide is a progressive clinical disorder which causes neurons to …

current quest in natural bioactive compounds for Alzheimer's disease: Multi-targeted-designed-ligand based approach with preclinical and clinical based evidence

A Iqubal, SO Rahman, M Ahmed, P Bansal… - Current Drug …, 2021 - ingentaconnect.com
Alzheimer's disease is a common and most chronic neurological disorder (NDs) associated
with cognitive dysfunction. Pathologically, Alzheimer's disease (AD) is characterized by the …