A review on the pharmacological effects of vitexin and isovitexin

M He, JW Min, WL Kong, XH He, JX Li, BW Peng - Fitoterapia, 2016 - Elsevier
Vitexin and isovitexin are active components of many traditional Chinese medicines, and
were found in various medicinal plants. Vitexin (apigenin-8-C-glucoside) has recently …

Molecular targets of vitexin and isovitexin in cancer therapy: a critical review

K Ganesan, B Xu - Annals of the New York Academy of …, 2017 - Wiley Online Library
Cancer is a primary public health problem and the second leading cause of death
worldwide. It causes life‐threatening malignancies and results in high financial costs for both …

Multitargeted effects of vitexin and isovitexin on diabetes mellitus and its complications

IL Abdulai, SK Kwofie, WS Gbewonyo… - The Scientific World …, 2021 - Wiley Online Library
Background. Till date, there is no known antidote to cure diabetes mellitus despite the
discovery and development of diverse pharmacotherapeutic agents many years ago …

Absorption, metabolism, and bioactivity of vitexin: recent advances in understanding the efficacy of an important nutraceutical

Y Peng, R Gan, H Li, M Yang… - Critical Reviews in …, 2021 - Taylor & Francis
Abstract vitexin, an apigenin-8-C-glucoside, is widely present in numerous edible and
medicinal plants. vitexin possesses a variety of bioactive properties, including antioxidation …

Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines

SM Borghi, TT Carvalho… - Journal of natural …, 2013 - ACS Publications
The flavonoid vitexin (1) is a flavone C-glycoside (apigenin-8-C-β-d-glucopyranoside)
present in several medicinal and other plants. Plant extracts containing 1 are reported to …

Phytochemical and Pharmacological Profile of Vitex negundo

CJ Zheng, HQ Li, SC Ren, CL Xu… - Phytotherapy …, 2015 - Wiley Online Library
The article aims to review all the chemical constituents and pharmacological properties of
Vitex negundo L.(Verbenaceae)(VN). VN is an important medicinal plant used as reputed …

[HTML][HTML] Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

N Kamal, NS Mio Asni, INA Rozlan, MAH Mohd Azmi… - Plants, 2022 - mdpi.com
The genus Vitex is also known as a chaste tree, in which it is a large shrub native to the
tropical and subtropical regions of the world. A diverse range of species is distributed …

The novel p53‐dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells

SH Yang, PH Liao, YF Pan, SL Chen… - Phytotherapy …, 2013 - Wiley Online Library
Vitexin, identified as apigenin‐8‐C‐D‐glucopyranoside, a natural flavonoid compound
found in certain herbs such as hawthorn herb, has been reported to exhibit anti‐oxidative …

[HTML][HTML] Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells

X Liu, Q Jiang, H Liu, S Luo - Biological research, 2019 - Springer
Background Currently, the prognosis of patients with non-small cell lung cancer (NSCLC)
remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side …

[HTML][HTML] Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway

CY Lee, YS Chien, TH Chiu, WW Huang… - Oncology …, 2012 - spandidos-publications.com
Vitexin, a lignan compound, has been shown to exert apoptotic actions on human breast
cancer cell lines and to have anti-inflammatory activities. Nevertheless, there is currently no …