We examined the role of macrophages in inflammation associated with colorectal cancer
(CRC). Given the emerging evidence on immune-microbiota interactions in CRC, we also …

Macrophages are critical players in the innate immune response to infectious challenge or
injury, initiating the innate immune response and directing the acquired immune response …

Inflammation is a critical player in the development of both colitis-associated and sporadic
colon cancers. Several studies suggest that the microbiota contribute to inflammation and …

Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial
distribution and cell interactions that shape macrophage tissue roles remain poorly …

Many lines of evidence demonstrate the associations of colorectal cancer (CRC) with
intestinal microbial dysbiosis. Recent reports have suggested that maintaining the …

Background & Aims Neutrophils are among the most prevalent immune cells in the
microenvironment of colon tumors; they are believed to promote growth of colon tumors, and …

Objectives Tumour-associated macrophages play an important role in mediating tumour
progression. In pancreatic cancer, infiltrating macrophages are known to mediate tumour …

Increasing evidence implicates the tumor microbiota as a factor that can influence cancer
progression. In patients with colorectal cancer (CRC), we found that pre-resection antibiotics …

Macrophages are frequently identified in solid tumors, playing important roles in cancer
progression. Their remarkable plasticity makes them very sensitive to environmental factors …

The colonic microbiome contributes to the initiation of colorectal cancer through poorly
characterized mechanisms. We have shown that commensal-polarized macrophages …