Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models

M Busch, H Brouwer, G Aalderink, G Bredeck… - Frontiers in …, 2023 - frontiersin.org
Plastic particles in the nanometer range–called nanoplastics–are environmental
contaminants with growing public health concern. As plastic particles are present in water …

[HTML][HTML] Can the impact of micro-and nanoplastics on human health really be assessed using in vitro models? A review of methodological issues

V Forest, J Pourchez - Environment International, 2023 - Elsevier
Because of the many advantages they offer (strength, low cost, durability, lightweight,
resistance, etc.), plastics are integral part of our daily life with a production constantly rising …

[HTML][HTML] Tiered testing of micro-and nanoplastics using intestinal in vitro models to support hazard assessments

G Bredeck, B Halamoda-Kenzaoui, A Bogni… - Environment …, 2022 - Elsevier
The uncertainty of potential risks associated with micro-and nanoplastics (MNPs) are of
growing public concern. However, the diversity of MNPs in the environment makes a …

Application of stem cells in the study of developmental and functional toxicity of endodermal-derived organs caused by nanoparticles

M Julaiti, H Guo, T Cui, N Nijiati, P Huang, B Hu - Toxicology in Vitro, 2024 - Elsevier
Nanoparticles have unique properties that make them useful in biomedicine. However, their
extensive use raises concerns about potential hazards to the body. Therefore, it is crucial to …

[HTML][HTML] Development of microfluidic, serum-free bronchial epithelial cells-on-a-chip to facilitate a more realistic in vitro testing of nanoplastics

G Gupta, S Vallabani, R Bordes, K Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
Most cell culture models are static, but the cellular microenvironment in the body is dynamic.
Here, we established a microfluidic-based in vitro model of human bronchial epithelial cells …

Potential human health effects following exposure to nano-and microplastics, lessons learned from nanomaterials

H Brouwer, FLN Van Oijen, H Bouwmeester - Present knowledge in food …, 2023 - Elsevier
A substantial part of the plastic produced worldwide ends up in the environment and
degrades into nano-and microplastics. The particles are ubiquitously present in the air and …

Emergence of nanoplastic in the environment and possible impact on human health

R Lehner, C Weder, A Petri-Fink… - … science & technology, 2019 - ACS Publications
On account of environmental concerns, the fate and adverse effects of plastics have
attracted considerable interest in the past few years. Recent studies have indicated the …

In vitro high-throughput toxicological assessment of nanoplastics

V Tolardo, D Magrì, F Fumagalli, D Cassano… - Nanomaterials, 2022 - mdpi.com
Sub-micrometer particles derived from the fragmentation of plastics in the environment can
enter the food chain and reach humans, posing significant health risks. To date, there is a …

Cytotoxicity Assessment of Nanoplastics and Plasticizers Exposure in In Vitro Lung Cell Culture Systems—A Systematic Review

F Clerigo, S Ferreira, C Ladeira, A Marques-Ramos… - Toxics, 2022 - mdpi.com
Emerging contaminants such as nanoplastics (NPs), as well as manufacturing by-products
such as plasticizers, have gained global attention and concern due to their limited …

Nanoplastics and human health: hazard identification and biointerface

H Lai, X Liu, M Qu - Nanomaterials, 2022 - mdpi.com
Nanoplastics are associated with several risks to the ecology and toxicity to humans.
Nanoplastics are synthetic polymers with dimensions ranging from 1 nm to 1 μm. They are …