The thalamus is a key cerebral hub relaying a multitude of corticoefferent and corticoafferent
connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural …

Background The thalamus is a major neural hub, with selective connections to virtually all
cortical regions of the brain. The multisystem neurodegenerative syndrome amyotrophic …

Background: While amyotrophic lateral sclerosis (ALS) is widely recognised as a multi-
network disorder with extensive frontotemporal and cerebellar involvement, sensory …

Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …

Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

The disease syndromes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia
(FTD) display considerable clinical, genetic and pathological overlap, yet mounting …

Objectives: To evaluate basal ganglia changes along the amyotrophic lateral sclerosis (ALS)–
ALS–frontotemporal dementia (FTD) continuum using multiple, complementary imaging …

Objectives: To characterize the nature and extent of basal ganglia involvement in
amyotrophic lateral sclerosis (ALS) genotypes in vivo. Methods: Forty-four healthy controls …

Background and Objectives A significant overlap between amyotrophic lateral sclerosis
(ALS) and behavioral variant of frontotemporal dementia (bvFTD) has been observed at …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …