Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic
prerequisite for sustainable growth and proliferation of tumor. Several growth factors …

Like any growing healthy tissues, tumors build up their blood vessels by three mechanisms:
angiogenesis, vasculogenesis, and intersucception. Vascular endothelial growth factor‐A …

Tumor cells cannot grow as a mass above 2 to 3 mm3 because diffusion is insufficient for
oxygen and glucose requirements, unless the tumor induces a blood supply. This …

In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that
tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors …

Neoangiogenesis, the development of new blood vessels from a pre-existing vasculature
involves the migration behavior, proliferation and differentiation of endothelial cells. This …

Etiological concepts on cancer development, malignant growth and tumour propagation
have undergone a revolutionary development during recent years: Among other aspects, the …

Advances in molecular biology have permitted the characterisation of mechanisms
underlying angiogenesis. Angiogenesis is a crucial process in tumour pathogenesis as it …

Angiogenesis is the physiological process of the formation of new blood vessels from pre-
existing ones. Multiple molecules regulate angiogenesis, such as the vascular endothelial …

Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …

Blood supply is essential for development and growth of tumors and angiogenesis is the
fundamental process of new blood vessel formation from preexisting ones. Angiogenesis is …