Association between infectious exposures in infancy and epigenetic age acceleration in young adulthood in metropolitan Cebu, Philippines

TW McDade, CP Ryan, LS Adair… - American Journal of …, 2023 - Wiley Online Library
Objectives The drivers of human life expectancy gains over the past 200 years are not well‐
established, with a potential role for historical reductions in infectious disease. We …

Susceptibility to infection in early life: a growing role for human genetics

A Borghesi, A Marzollo, A Michev, J Fellay - Human genetics, 2020 - Springer
The unique vulnerability to infection of newborns and young infants is generally explained
by a constellation of differences between early-life immune responses and immune …

The emergence of epidemiology in the genomics age

MJ Khoury, R Millikan, J Little… - International Journal of …, 2004 - academic.oup.com
While observational epidemiology is considered to be the scientific foundation of public
health2 it is often viewed as a 'soft science'limited by an inherent inability to fully control for …

Lifecourse epidemiology and molecular pathological epidemiology

A Nishi, I Kawachi, KC Koenen, K Wu… - American journal of …, 2015 - Elsevier
Lifecourse epidemiology studies long-term effects of social and environmental exposures on
health and disease. 1, 2 A key challenge to the three models of lifecourse epidemiology is …

[PDF][PDF] Early childhood factors and health pathways to disability and death in mid-ages—a multi-state time-to-event life history model.

LK Raut - lakshmiraut.github.io
Developmental programming literature in microbiology emphasizes that much of the process
of health development throughout life is determined at the early stage of life by the early …

Statistical and conceptual considerations in socioepigenomics research on childhood adversity and epigenetic aging

EC Dunn, AJ Simpkin, E Walton - JAMA Network Open, 2023 - jamanetwork.com
Applications of epigenetic clocks to health questions have proliferated over the past decade,
particularly as a means of understanding disease etiology. Epigenetic clocks are aggregate …

Life‐threatening infectious diseases of childhood: single‐gene inborn errors of immunity?

A Alcaïs, L Quintana‐Murci, DS Thaler… - Annals of the New …, 2010 - Wiley Online Library
The hypothesis that inborn errors of immunity underlie infectious diseases is gaining
experimental support. However, the apparent modes of inheritance of predisposition or …

Does exposure to infectious diseases in infancy affect old-age mortality? Evidence from a pre-industrial population

A Gagnon, R Mazan - Social Science & Medicine, 2009 - Elsevier
Many studies have shown that health conditions experienced in childhood play an important
role on an individual's adult mortality. Recent research suggests that past reductions in early …

Evolutionary determinants of genetic variation in susceptibility to infectious diseases in humans

C Baker, J Antonovics - PLoS One, 2012 - journals.plos.org
Although genetic variation among humans in their susceptibility to infectious diseases has
long been appreciated, little focus has been devoted to identifying patterns in levels of …