Antibiotics can induce mutations that cause antibiotic resistance. Yet, despite their
importance, mechanisms of antibiotic-promoted mutagenesis remain elusive. We report that …

Mechanisms of evolution and evolution of antibiotic resistance are both fundamental and
world health problems. Stress-induced mutagenesis defines mechanisms of mutagenesis …

Exposure to antibiotics induces the expression of mutagenic bacterial stress–response
pathways, but the evolutionary benefits of these responses remain unclear. One possibility is …

The SOS response to DNA damage is a conserved stress response in Gram-negative and
Gram-positive bacteria. Although this pathway has been studied for years, its relevance is …

Antibiotic resistance arises through mechanisms such as selection of naturally occurring
resistant mutants and horizontal gene transfer. Recently, oxidative stress has been …

Evolutionary theory assumed that mutations occur constantly, gradually, and randomly over
time. This formulation from the “modern synthesis” of the 1930s was embraced decades …

Although it is well known that microbial populations can respond adaptively to challenges
from antibiotics, empirical difficulties in distinguishing the roles of de novo mutation and …

The development of antibiotic resistance poses an increasing threat to global health.
Understanding how resistance develops in bacteria is critical for the advancement of new …

Special mechanisms of mutation are induced in microbes under growth-limiting stress
causing genetic instability, including occasional adaptive mutations that may speed …

Bacteria can rapidly evolve resistance to antibiotics via the SOS response, a state of high-
activity DNA repair and mutagenesis. We explore here the first steps of this evolution in the …