Functional genomic hypothesis generation and experimentation by a robot scientist

RD King, KE Whelan, FM Jones, PGK Reiser… - Nature, 2004 - nature.com
The question of whether it is possible to automate the scientific process is of both great
theoretical interest, and increasing practical importance because, in many scientific areas …

[HTML][HTML] Towards robot scientists for autonomous scientific discovery

A Sparkes, W Aubrey, E Byrne, A Clare… - Automated …, 2010 - Springer
We review the main components of autonomous scientific discovery, and how they lead to
the concept of a Robot Scientist. This is a system which uses techniques from artificial …

An autonomous molecular computer for logical control of gene expression

Y Benenson, B Gil, U Ben-Dor, R Adar, E Shapiro - Nature, 2004 - nature.com
Early biomolecular computer research focused on laboratory-scale, human-operated
computers for complex computational problems,,,,,,. Recently, simple molecular-scale …

Five hard truths for synthetic biology.

R Kwok - Nature, 2010 - search.ebscohost.com
The article reports on the effect of several key challenges including circuitry, unmanageable
complexity, and variability on synthetic biology. It notes that synthetic biology could provide a …

From DNA sequence to biological function

SG Oliver - Nature, 1996 - nature.com
Genome sequencing is leading to the discovery of new genes at a rate 50–100 times greater
than that achieved by classical genetics, but the biological function of almost half of these …

Controlling an organic synthesis robot with machine learning to search for new reactivity

JM Granda, L Donina, V Dragone, DL Long, L Cronin - Nature, 2018 - nature.com
The discovery of chemical reactions is an inherently unpredictable and time-consuming
process. An attractive alternative is to predict reactivity, although relevant approaches, such …

[引用][C] Challenging times for bioinformatics

G Casari, MA Andrade, P Bork, J Boyle, A Daruvar… - Nature, 1995 - nature.com
SIR-On July 28, 1995, the timely public release of the complete DNA sequence of
Haemophilus influenzae Rd made the world of biology richer, in one day, by 1,830,137 …

Opportunities at the intersection of synthetic biology, machine learning, and automation

P Carbonell, T Radivojevic… - ACS synthetic biology, 2019 - ACS Publications
Our inability to predict the behavior of biological systems severely hampers progress in
bioengineering and biomedical applications. We cannot predict the effect of genotype …

[PDF][PDF] Is there an intelligent agent in your future?

J Hendler - Nature, 1999 - math.pku.edu.cn
Imagine that you are lucky enough to find some free time in your schedule, a you decide to
take a trip. What do you do? If you're like most people, you co a travel agent to arrange the …

Organic synthesis in a modular robotic system driven by a chemical programming language

S Steiner, J Wolf, S Glatzel, A Andreou, JM Granda… - Science, 2019 - science.org
INTRODUCTION Outside of a few well-defined areas such as polypeptide and
oligonucleotide chemistry, the automation of chemical synthesis has been limited to large …