A Fluorinated Supramolecular Self‐Assembled Peptide as Nanovaccine Adjuvant for Enhanced Cancer Vaccine Therapy

S Jia, S Ji, J Zhao, Y Lv, J Wang, D Sun… - Small …, 2023 - Wiley Online Library
Adjuvants play an important role in enhancing vaccine‐induced immune protection.
Adequate cellular uptake, robust lysosomal escape, and subsequent antigen cross …

A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

YR Zhan, X He, ZY Huang, P Chen, MM Tian… - Journal of Materials …, 2023 - pubs.rsc.org
The inefficient treatment using protein-based nanovaccines is largely attributed to their
inadequate immunogenicity. Herein, we developed a novel fluoropolymer (PF) via ring …

A Nanovaccine Based on Adjuvant Peptide FK‐13 and l‐Phenylalanine Poly(ester amide) Enhances CD8+ T Cell‐Mediated Antitumor Immunity

C Xie, X You, H Zhang, J Li, L Wang, Y Liu… - Advanced …, 2023 - Wiley Online Library
Cancer vaccines have shown promise as effective means of antitumor immunotherapy by
inducing tumor antigen‐specific T cell immunity. In this study, a novel peptide‐based tumor …

Engineering dendritic-cell-based vaccines and PD-1 blockade in self-assembled peptide nanofibrous hydrogel to amplify antitumor T-cell immunity

P Yang, H Song, Y Qin, P Huang, C Zhang, D Kong… - Nano …, 2018 - ACS Publications
Dendritic cells (DCs) are increasingly used in cancer vaccines due to their ability to regulate
T-cell immunity. Major limitations associated with the present DC adoptive transfer …

[HTML][HTML] Self-assembly nanovaccine containing TLR7/8 agonist and STAT3 inhibitor enhances tumor immunotherapy by augmenting tumor-specific immune response

L Zhang, J Huang, X Chen, C Pan, Y He… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Cancer vaccines are a promising strategy for cancer immunotherapy. Cancer
vaccines elicits a specific cytotoxic immune response to tumor antigens. However, the …

[HTML][HTML] A versatile supramolecular nanoadjuvant that activates NF-κB for cancer immunotherapy

Y Xu, Y Wang, Q Yang, Z Liu, Z Xiao, Z Le, Z Yang… - Theranostics, 2019 - ncbi.nlm.nih.gov
Although powerful adjuvants hold promise of vaccines for cancer immunotherapy,
cumbersome preparation processes, elusive mechanisms and failure to induce T cell …

[HTML][HTML] Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB …

Q Su, H Song, P Huang, C Zhang, J Yang, D Kong… - Bioactive Materials, 2021 - Elsevier
Peptide vaccine targeting tumor-specific antigens is a promising cancer treatment regimen.
However, peptide vaccines are commonly low-immunogenic, leading to suboptimal …

Nanoscale coordination polymer based nanovaccine for tumor immunotherapy

H Zhao, J Xu, Y Li, X Guan, X Han, Y Xu, H Zhou… - Acs Nano, 2019 - ACS Publications
Tumor vaccines to induce robust immunity for cancer treatment have attracted tremendous
interests in cancer immunotherapy. In this work, a type of cancer vaccine is prepared by …

Highly Enhanced Antitumor Immunity by a Three-Barreled Strategy of the l-Arginine-Promoted Nanovaccine and Gene-Mediated PD-L1 Blockade

Y Hu, L Lin, J Chen, K Hao, S Zhang… - … Applied Materials & …, 2020 - ACS Publications
Weak T cell responses and immune checkpoints within tumors could be two key factors for
limiting antitumor efficacy in the field of cancer immunotherapy. Thus, the combined strategy …

A self-adjuvanting anti-tumor nanoliposomal vaccine based on fluorine-substituted MUC1 glycopeptide

P Dong, S Cheng, Y Wang, H Gao, Y Zhang… - Chemical …, 2022 - pubs.rsc.org
A self-adjuvanting anti-tumor nanoliposomal vaccine based on fluorine-substituted MUC1
glycopeptide - Chemical Communications (RSC Publishing) DOI:10.1039/D2CC02143A …