The hedgehog pathway, initially discovered by two Nobel laureates Drs E Wieschaus and C
Nusslein-Volhard in Drosophila, is a major regulator for cell differentiation, tissue polarity …

The Hedgehog pathway is essential for embryonic development but also for tissue and
organ homeostasis in adult organisms. Activation of this pathway leads to the expression of …

Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an
evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth …

Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980,
hedgehog (Hh) signaling has been implicated in regulation of cell differentiation …

Abstract The Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most
animals and is crucial for proper development. At the molecular level, Hh ligands drive cell …

Hedgehog (Hh) signaling is an important factor in growth and patterning during embryonic
development. A mutation in Patched, Smoothened or Gli1, which regulate the Hh signaling …

The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in
vertebrate embryonic development including stem cell maintenance, cell differentiation …

Cancer poses a serious health problem in society and is increasingly surpassing
cardiovascular disease as the leading cause of mortality in the United States. Current …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

The Hedgehog signalling pathway is essential for numerous processes during embryonic
development. Members of this family of secreted proteins control cell proliferation …