Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …

Liver fibrosis is the most common pathway in most types of chronic liver damage,
characterized by an imbalance of ECM degradation and synthesis. Saikosaponin-d (SSd) …

Background Hepatic fibrosis is the final pathway of chronic liver disease characterized by
excessive accumulation of extracellular matrix (ECM), which eventually develop into …

NLRP3 inflammasome activation results in severe liver inflammation and injury.
Saikosaponin-d (SSd) possesses anti-inflammatory and hepatoprotective effects. This study …

Saikosaponin-d (SSd) is one of the major triterpenoid saponins derived from Bupleurum
falcatum L., which has been reported to possess antifibrotic activity. At present, there is little …

Treatment of liver fibrosis and cirrhosis remains a challenging field. Hepatocyte injury and
the activation of hepatic stellate cells are the 2 major events in the development of liver …

Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from
Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present …

The aim of this study was to investigate the effects of SSa on LPS-induced endotoxemia in
mice and clarify the possible mechanism. An LPS-induced endotoxemia mouse model was …

Liver fibrosis is the consequence of chronic liver injury and is a major challenge to global
health. However, successful therapy for liver fibrosis is still lacking. Sennoside A (SA), a …

Pancreatic stellate cells (PSCs) are the main effector cells in the development of pancreatic
fibrosis. Finding substances that inhibit PSC activation is an important approach to inhibiting …