Precise and efficient regulation of microglia is vital for ischemic stroke therapy and
prognosis. The infiltration of neutrophils into the brain provides opportunities for regulatory …

Traumatic brain injuries (TBI) and stroke are major causes of morbidity and mortality in both
developing and developed countries. The complex and heterogeneous pathophysiology of …

Neuroinflammation has emerged as a major concern in ischemic stroke therapy because it
exacebates neurological dysfunction and suppresses neurological recovery after …

Ischemic stroke (IS) constitutes the leading cause of global morbidity and mortality.
Neuroprotectants are essential to ameliorate the clinical prognosis, but their therapeutic …

In acute ischemic stroke, neutrophils contribute to ischemia-reperfusion injury through
producing neutrophil extracellular traps (NETs), which promote the interaction of platelets …

High level of detrimental factors including reactive oxygen species (ROS) and inflammatory
cytokines accumulated in the infarct core and their erosion to salvageable penumbra are key …

Brain inflammation is regarded as one of the leading causes that aggravates secondary
brain injury and hinders the prognosis of ischemic stroke. After ischemic stroke, high …

Neutrophils are associated with pro‐inflammation and contribute to pathophysiology of
ischemic stroke. Prevention of neutrophils from infiltrating into ischemic area can be a …

Reperfusion injury of ischemic stroke, characterized by the uncontrolled production of
reactive oxygen species (ROS) and inflammatory reactions, continues to present a major …

The treatment of reperfusion injury after ischemic stroke remains unsatisfactory since the
blood‐brain barrier (BBB) prevents most neuroprotective agents from entering the brain …