Protein degradation is a universal process performed by human cells to recycle unused
proteins and to adapt to an ever-changing environment. Targeted protein degradation (TPD) …

Targeted protein degradation is becoming a weapon of choice against targets considered
heretofore “undruggable.” Whereas most small molecules inhibit a protein by blocking its …

Squalene synthase (SQS) is an essential enzyme in the mevalonate pathway, which
controls cholesterol biosynthesis and homeostasis. Although catalytic inhibitors of SQS have …

Targeted protein degradation by small-molecule degraders represents a new and exciting
mode of action in drug discovery. Proteolysis-targeting chimeras (PROTACs) represent a …

Small molecules continue to dominate drug discovery because of their ease of use, lower
cost of manufacturing, and access to intracellular targets. However, despite these …

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target
through conventional methods or have not yet been targeted, but are of great clinical …

In the constant pursuit of medicinal chemistry to expand the druggable space and develop
novel strategies to target essential disease driving proteins, small-molecule-induced protein …

Inducing Targeted Protein Degradation Enables drug developers in academia and industry
to expand the range of accessible drug targets through induced protein degradation Since …

Molecules designed to induce ubiquitylation and subsequent degradation of specific target
proteins have become the focus of intense research interest across the biotech and …

Targeted Protein Degradation (TPD) is an emerging new modality of drug discovery that
offers unprecedented therapeutic benefits over traditional protein inhibition. Most …