[HTML][HTML] Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma
Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …
Single-cell RNA sequencing of childhood ependymoma reveals neoplastic cell subpopulations that impact molecular classification and etiology
Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in
most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly …
most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly …
[HTML][HTML] Current therapy and the evolving molecular landscape of paediatric ependymoma
S Khatua, V Ramaswamy, E Bouffet - European Journal of Cancer, 2017 - Elsevier
Ependymomas are the third commonest paediatric central nervous system (CNS) tumour,
accounting for 6–12% of brain tumours in children. The management of these tumours has …
accounting for 6–12% of brain tumours in children. The management of these tumours has …
Ependymoma
ER Gerstner, KW Pajtler - Seminars in neurology, 2018 - thieme-connect.com
Ependymoma can arise throughout the whole neuraxis. In children, tumors predominantly
occur intracranially, whereas the spine is the most prevalent location in adults. Significant …
occur intracranially, whereas the spine is the most prevalent location in adults. Significant …
Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas
Childhood posterior fossa group A ependymomas (PFAs) have limited treatment options and
bear dismal prognoses compared to group B ependymomas (PFBs). PFAs overexpress the …
bear dismal prognoses compared to group B ependymomas (PFBs). PFAs overexpress the …
[HTML][HTML] Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma
Despite the histological similarity of ependymomas from throughout the neuroaxis, the
disease likely comprises multiple independent entities, each with a distinct molecular …
disease likely comprises multiple independent entities, each with a distinct molecular …
Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas
Purpose The molecular pathogenesis of pediatric ependymoma remains unclear. Our study
was designed to identify genetic changes implicated in ependymoma progression. Patients …
was designed to identify genetic changes implicated in ependymoma progression. Patients …
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Genomic sequencing has driven precision-based oncology therapy; however, the genetic
drivers of many malignancies remain unknown or non-targetable, so alternative approaches …
drivers of many malignancies remain unknown or non-targetable, so alternative approaches …
The molecular biology of ependymomas
RL Hamilton, IF Pollack - Brain pathology, 1997 - Wiley Online Library
Intracranial ependymomas are the third most common primary brain tumor in the pediatric
population. Although an anaplastic variant is recognized, numerous studies examining the …
population. Although an anaplastic variant is recognized, numerous studies examining the …
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors
P Sievers, SC Henneken, C Blume, M Sill… - Acta …, 2021 - Springer
Ependymomas encompass a heterogeneous group of central nervous system (CNS)
neoplasms that occur along the entire neuroaxis. In recent years, extensive (epi-) genomic …
neoplasms that occur along the entire neuroaxis. In recent years, extensive (epi-) genomic …