Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis

D Doens, PL Fernández - Journal of neuroinflammation, 2014 - Springer
Alzheimer's disease (AD) is a major public health problem with substantial economic and
social impacts around the world. The hallmarks of AD pathogenesis include deposition of …

Microglial activation in Alzheimer's disease

J Schlachetzki, M Hull - Current Alzheimer Research, 2009 - ingentaconnect.com
Alzheimer's disease (AD) is a devastating chronic neurodegenerative disease with currently
no available disease modifying treatment. In recent years, the peptide amyloid-β has been …

Innate immunity in Alzheimer's disease: a complex affair

MV Guillot-Sestier, T Town - CNS & Neurological Disorders …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is characterized by three major histopathological hallmarks: β-
amyloid deposits, neurofibrillary tangles and gliosis. While neglected for decades, the …

Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation

S Anwar, S Rivest - Expert opinion on therapeutic targets, 2020 - Taylor & Francis
Introduction: Despite the revolutionary progress in neurodegenerative disease research,
there is no cure for Alzheimer's disease (AD). This is a chronic progressive …

Immunological aspects of microglia: relevance to Alzheimer's disease

EN Benveniste, VT Nguyen, GM O'Keefe - Neurochemistry international, 2001 - Elsevier
Alzheimer's disease (AD) is a progressive dementing neurologic illness, and the most
frequent cause of dementia in the elderly. Neuritic plaques are one of the main …

[HTML][HTML] Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease

WY Wang, MS Tan, JT Yu, L Tan - Annals of translational medicine, 2015 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is
characterized by the formation of extracellular amyloid plaques (or senile plaques) and …

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

A Webers, MT Heneka… - Immunology and cell …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation, tau pathology
and neuroinflammation. Recently, there has been considerable interest in the role of …

Microglia in Alzheimer's disease: a multifaceted relationship

A ElAli, S Rivest - Brain, behavior, and immunity, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting elderly
people worldwide, which is mainly characterized by cerebral amyloid-beta (Aβ) plaque …

Microglia in Alzheimer′ s Disease: It′ s All About Context

TM Weitz, T Town - International journal of Alzheimer's disease, 2012 - Wiley Online Library
Neuroinflammation is now regarded as both an early event and prime mover in the
pathobiology of Alzheimer disease (AD), a neurodegenerative disease that represents a …

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease

DA Dionisio-Santos, JA Olschowka… - Journal of …, 2019 - Springer
Neuroinflammation is considered one of the cardinal features of Alzheimer's disease (AD).
Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are …