Phosphate is essential for numerous biological processes, and serum levels are tightly
regulated to accomplish these functions. The regulation of serum phosphate in a narrow …

FGF23 discovery has uncovered primary regulatory pathways and new systems biology
governing bone mineralization, vitamin D metabolism, parathyroid gland function, and renal …

Abstract Fibroblast growth factor 23 (FGF23) was identified in 2000. Since then, FGF23 has
been found to physiologically regulate phosphate metabolism and aberrant actions of …

Phosphate is a cornerstone of several physiological pathways including skeletal
development, bone mineralization, membrane composition, nucleotide structure …

It is well known that fibroblast growth factor (FGF) family members are associated with
embryonic development and are critical for basic metabolic functions. This review will focus …

Abstract Purpose of Review Fibroblast growth factor 23 (FGF23) is a bone-and bone marrow-
derived hormone that is critical to maintain phosphate homeostasis. The principal actions of …

Chronic kidney disease (CKD) is associated with distinct alterations in mineral metabolism
in children and adults resulting in multiple organ dysfunctions. Children with advanced CKD …

FGF23 was identified as a humoral factor involved in the development of several
hypophosphatemic diseases about 10 years ago. Since then, it has been shown that FGF23 …

The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with
parathyroid hormone (PTH) and the active vitamin D metabolite, 1, 25 (OH) 2 vitamin D (1 …

Abstract Fibroblast growth factor 23 (FGF23) is a protein produced by mature osteoblasts
involved in mineral homeostasis by binding to its receptor complex FGFR/Klotho located …