Neurons display extreme degrees of polarization, including compartment-specific organelle
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …

Synaptic transmission is bioenergetically demanding, and the diverse processes underlying
synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP …

The proper intracellular distribution of mitochondria is assumed to be critical for normal
physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or …

Mitochondria are widely distributed via regulated transport in neurons, but their sites of
biogenesis remain uncertain. Most mitochondrial proteins are encoded in the nuclear …

Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins,
Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These …

Proper distribution of mitochondria within axons and at synapses is critical for neuronal
function. While one-third of axonal mitochondria are mobile, a large proportion remains in a …

Synapses are the regions of the neuron that enable the transmission and propagation of
action potentials on the cost of high energy consumption and elevated demand for …

Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons
use specialized mechanisms to drive mitochondria transport and to anchor them in axons …

Mitochondrial dysfunction plays a central role in glutamate-evoked neuronal excitotoxicity,
and mitochondrial fission/fusion dynamics are essential for mitochondrial morphology and …

Mitochondria dynamically change their shape by repeated fission and fusion in response to
physiological and pathological conditions. Recent studies have uncovered significant roles …