Cardiac electrophysiology is regulated by continuous trafficking and internalization of ion
channels occurring over minutes to hours. Kv11. 1 (also known as hERG) underlies the …

The rapid delayed rectifier current IKr is one of the major K+ currents involved in
repolarization of the human cardiac action potential. Various inherited or drug-induced forms …

Both inherited and acquired cardiac arrhythmias are often associated with the abnormal
functional expression of ion channels at the cellular level. The complex machinery that …

Abstract The Kv11. 1 (also ERG1) K+ channel underlies cardiac IKr, a current that
contributes to repolarization in mammalian heart. In mice, IKr current density decreases with …

Aims To study the properties of ion-channel gating (I Ks, the slow delayed rectifier K+
channel) that underlie the channel's participation in rate-dependent repolarization of the …

Ion channels are the “building blocks” of the excitation process in excitable tissues. Despite
advances in determining their molecular structure, understanding the relationship between …

The heartbeat originates from spontaneous action potentials in specialized pacemaker cells
within the sinoatrial node (SAN) of the right atrium. Voltage-gated potassium channels in …

IKr is the rapidly activating component of the delayed rectifier potassium current, the ion
current largely responsible for the repolarization of the cardiac action potential. Inherited …

The number of ion channels expressed on the cell surface shapes the complex electrical
response of excitable cells. Maintaining a balance between anterograde and retrograde …

Voltage-gated potassium 11.1 (Kv11. 1) channels play a critical role in repolarization of
cardiomyocytes during the cardiac action potential (AP). Drug-mediated Kv11. 1 blockade …