Osteoarthritis (OA) is a whole joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors. The disease is multifactorial and polygenic, and its …

Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Due to an increasing life expectance, osteoarthritis (OA) is one of the most common chronic
diseases. Although strong efforts have been made to regenerate degenerated joint cartilage …

Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible
structural and functional changes in the joint and is a major cause of disability and reduced …

Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

Objectives: The metabolism of cells in articular joint tissues in normal and pathological
conditions is subject to a complex environmental control. In addition to soluble mediators …

The degenerative joint disease osteoarthritis (OA) is the most prevalent form of chronic
musculoskeletal disease worldwide, and it commonly afflicts the elderly population. OA …

Objectives: To determine the regulatory effects of reactive oxygen species (ROS) on the
expression by human osteoarthritic chondrocytes of interleukin (IL)-1β,-6 and-8, inducible …

There are numerous extra-and intra-cellular processes involved in the production of reactive
oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules …

Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …