Highlights•We review recent studies on genetic systems of obligate intracellular
pathogens.•We identify key advances in the use of genetic systems over the past two …

Infections by obligate intracellular bacterial pathogens result in significant morbidity and
mortality worldwide. These bacteria include Chlamydia spp., which causes millions of cases …

A century ago, Gertrude Stein told us that a rose is a rose is a rose, but today, modern
genomics is telling us that a pathogen is not a pathogen. Advances in pathogenomics have …

Pathogenic mechanisms of intracellular bacteria : Current Opinion in Infectious Diseases
Pathogenic mechanisms of intracellular bacteria : Current Opinion in Infectious Diseases Log in …

The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host-pathogen interactions at the molecular level and is critical for devising …

I ntracellular bacterial pathogens are responsible for a significant number and variety of
human diseases, including tuberculosis, trachoma, enteric infections and meningitis …

It is common knowledge that pathogenic viruses can change hosts, with avian influenza, the
HIV, and the causal agent of variant Creutzfeldt–Jacob encephalitis as well-known …

Analysing the genomes of non-pathogenic microorganisms, in addition to its basic and
applied scientific interest, can also shed considerable light on the study of pathogenic …

The acquisition of DNA by horizontal gene transfer enables bacteria to adapt to previously
unexploited ecological niches. Although horizontal gene transfer and mutation of protein …

Viewpoints regarding the evolution of pathogenic bacteria have themselves evolved over
the past two decades. Although it is perhaps extreme to suggest different teleological camps …