Rationale: The β2-adrenoceptor (β2-AR), a prototypical GPCR (G protein-coupled receptor),
couples to both Gs and Gi proteins. Stimulation of the β2-AR is beneficial to humans and …

Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …

β-adrenergic receptor (AR) subtypes are archetypical members of the G protein-coupled
receptor (GPCR) superfamily. Whereas both β1AR and β2AR stimulate the classic Gs …

The stimulation of β-adrenergic receptor (βAR) plays a pivotal role in regulating myocardial
function and morphology in the normal and failing heart. Three genetically and …

Publisher Summary This chapter discusses the β-adrenergic receptor (βAR) subtype
signaling in the heart. The stimulation of βAR, a prototypical member of G protein-coupled …

β-adrenoceptors are members of the G protein-coupled receptor superfamily which play a
key role in the regulation of myocardial function. Their activation increases cardiac …

As heart failure (HF) is a growing public health problem worldwide, rapid therapeutic
development is required to improve HF management. Decreased myocardial contractility in …

Abstract β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …

Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …

Abstract Background β 1-and β 2–adrenergic receptors (ARs) play distinct roles in the heart,
eg β 1 AR is pro-contractile and pro-apoptotic but β 2 AR anti-apoptotic and only weakly pro …