Heterodimerization With 5-HT2BR Is Indispensable for β2AR-Mediated Cardioprotection
Y Song, C Xu, J Liu, Y Li, H Wang, D Shan… - Circulation …, 2021 - Am Heart Assoc
Rationale: The β2-adrenoceptor (β2-AR), a prototypical GPCR (G protein-coupled receptor),
couples to both Gs and Gi proteins. Stimulation of the β2-AR is beneficial to humans and …
couples to both Gs and Gi proteins. Stimulation of the β2-AR is beneficial to humans and …
[HTML][HTML] Targeting β3-adrenergic receptors in the heart: selective agonism and β-blockade
Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …
β-Adrenergic Signaling in the Heart: Dual Coupling of the β2-Adrenergic Receptor to Gs and Gi Proteins
RP Xiao - Science's STKE, 2001 - science.org
β-adrenergic receptor (AR) subtypes are archetypical members of the G protein-coupled
receptor (GPCR) superfamily. Whereas both β1AR and β2AR stimulate the classic Gs …
receptor (GPCR) superfamily. Whereas both β1AR and β2AR stimulate the classic Gs …
Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
M Zheng, W Zhu, Q Han, RP Xiao - Pharmacology & therapeutics, 2005 - Elsevier
The stimulation of β-adrenergic receptor (βAR) plays a pivotal role in regulating myocardial
function and morphology in the normal and failing heart. Three genetically and …
function and morphology in the normal and failing heart. Three genetically and …
β-adrenergic receptor subtype signaling in the heart: from bench to the bedside
W Zhu, AYH Woo, Y Zhang, CM Cao… - Current topics in …, 2011 - Elsevier
Publisher Summary This chapter discusses the β-adrenergic receptor (βAR) subtype
signaling in the heart. The stimulation of βAR, a prototypical member of G protein-coupled …
signaling in the heart. The stimulation of βAR, a prototypical member of G protein-coupled …
Pathophysiological relevance of the cardiac β2-adrenergic receptor and its potential as a therapeutic target to improve cardiac function
J Pérez-Schindler, A Philp… - European journal of …, 2013 - Elsevier
β-adrenoceptors are members of the G protein-coupled receptor superfamily which play a
key role in the regulation of myocardial function. Their activation increases cardiac …
key role in the regulation of myocardial function. Their activation increases cardiac …
Beta-3 adrenoceptors: A potential therapeutic target for heart disease
G Kayki-Mutlu, I Karaomerlioglu, E Arioglu-Inan… - European journal of …, 2019 - Elsevier
As heart failure (HF) is a growing public health problem worldwide, rapid therapeutic
development is required to improve HF management. Decreased myocardial contractility in …
development is required to improve HF management. Decreased myocardial contractility in …
β-Adrenergic receptor, an essential target in cardiovascular diseases
Abstract β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …
Cardiac salvage by tweaking with beta-3-adrenergic receptors
JL Balligand - Cardiovascular research, 2016 - academic.oup.com
Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …
[HTML][HTML] GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility
NC Salazar, X Vallejos, A Siryk, G Rengo… - Cell Communication and …, 2013 - Springer
Abstract Background β 1-and β 2–adrenergic receptors (ARs) play distinct roles in the heart,
eg β 1 AR is pro-contractile and pro-apoptotic but β 2 AR anti-apoptotic and only weakly pro …
eg β 1 AR is pro-contractile and pro-apoptotic but β 2 AR anti-apoptotic and only weakly pro …