Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an
action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and …

Topical analgesics may play an important role in the management of chronic pain and have
good tolerability. Systemic ketamine has limited usage as an anesthetic and along with its …

Ketamine is a dissociative anesthetic and its primary mechanism of action is considered to
be through antagonism of the N-methyl-D-aspartate (NMDA) receptor. For many years it has …

Ketamine is a parenteral anesthetic agent that provides analgesic activity at sub-anesthetic
doses. It is an N-methyl-D-aspartate (NMDA) receptor antagonist with opioid receptor …

Ketamine is an injectable anesthetic induction agent that has been reported to have
analgesic activity in pain from a variety of mechanisms, but predominantly in neuralgic and …

Ketamine has diverse effects that may be of relevance to chronic pain including: N-methyl-d-
aspartic acid, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, kainate, γ …

Unlabelled BACKGROUND. This study examined the analgesic effect of local ketamine
infiltration, compared with placebo and systemic ketamine, in a human model of …

Ketamine is an N-methyl-D-aspar tate receptor antagonist that has been in clinical use in the
USA for over 30 years. Its ability to provide profound analgesia and amnesia while …

Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used
recently for analgesia in patients with chronic pain. Twenty-one patients with chronic …

Background: The n-methyl-d-aspartate receptor antagonists such as ketamine relieve
chronic pain but their oral and parenteral use is limited by the adverse effects. Experimental …