Propagation of gene-expression patterns through the cell cycle requires the existence of an
epigenetic mark that re-establishes the chromatin architecture of the parental cell in the …

Histone modifications are thought to regulate gene expression in part by modulating DNA
accessibility. Here, we measured genome-wide DNA accessibility in Drosophila …

Duplication of eukaryotic genomes during S phase is coordinated in space and time. In
order to identify zones of initiation and cell-type-as well as gender-specific plasticity of DNA …

The genome is subject to a diverse array of epigenetic modifications from DNA methylation
to histone posttranslational changes. Many of these marks are somatically stable through …

Epigenetic modifications influence gene expression pattern and provide a unique signature
of a cell differentiation status. Without external stimuli or signalling events, this cell identity …

Polycomb group (PcG) and trithorax group (trxG) proteins act as antagonistic regulators to
maintain transcriptional OFF and ON states of HOX and other target genes. To study the …

The polytene chromosomes of Drosophila melanogaster consist of condensed
heterochromatin regions most of which are in the chromocenter, telomeres, and the fourth …

We have identified a novel gene named grappa (gpp) that is the Drosophila ortholog of the
Saccharomyces cerevisiae gene Dot1, a histone methyltransferase that modifies the lysine …

The replication of a chromosomal region during S phase can be highly dynamic between
cell types that differ in transcriptome and epigenome. Early replication timing has been …

The packaging of regulatory DNA within the eukaryotic chromosome has considerable
potential not only for modulating the transcriptional activity of genes, but also for propagating …