Modeling, optimization and experimental assessment of continuous L‐(−)‐carnitine production by Escherichia coli cultures
F Alvarez‐Vasquez, M Canovas… - Biotechnology and …, 2002 - Wiley Online Library
In a previous paper Cánovas et al.(Biotechnol Bioeng 2002; 77: 764–775) presented a
model for L-(−)-carnitine production using Escherichia coli O44 K74, in a cell-recycle …
model for L-(−)-carnitine production using Escherichia coli O44 K74, in a cell-recycle …
Design of Metabolic Engineering Strategies for Maximizing l‐(–)‐Carnitine Production by Escherichia coli. Integration of the Metabolic and Bioreactor Levels
In this work metabolic engineering strategies for maximizing l‐(–)‐carnitine production by
Escherichia coli based on the Biochemical System Theory (1–3) and the Indirect …
Escherichia coli based on the Biochemical System Theory (1–3) and the Indirect …
High-density Escherichia coli cultures for continuous l(−)-carnitine production
The use of a biological procedure for l-carnitine production as an alternative to chemical
methods must be accompanied by an efficient and highly productive reaction system …
methods must be accompanied by an efficient and highly productive reaction system …
L (-)-carnitine production using a recombinant Escherichia coli strain
The L (-)-carnitine production by biotransformation using the recombinant strain Escherichia
coli pT7-5KE32 has been studied and optimized with crotonobetaine and D (+)-carnitine as …
coli pT7-5KE32 has been studied and optimized with crotonobetaine and D (+)-carnitine as …
Modeling analysis of the L (−)-carnitine production process by Escherichia coli
The basis of a previous model for the crotonobetaine biotransformation into l (−)-carnitine by
Escherichia coli strains [Cánovas M, Maiquez JR, Obon JM, Iborra JL. Modeling of the …
Escherichia coli strains [Cánovas M, Maiquez JR, Obon JM, Iborra JL. Modeling of the …
Continuous cell-recycle process for L-carnitine production: performance, engineering and downstream processing aspects compared with discontinuous processes
F Hoeks, H Kulla, HP Meyer - Journal of biotechnology, 1992 - Elsevier
For the biotransformation of y-butyrobetaine into L-carnitine, a chemostat with cell-recycling
and a fed-batch process were developed and compared. Different cell recycling systems …
and a fed-batch process were developed and compared. Different cell recycling systems …
Production of L-carnitine by secondary metabolism of bacteria
The increasing commercial demand for L-carnitine has led to a multiplication of efforts to
improve its production with bacteria. The use of different cell environments, such as growing …
improve its production with bacteria. The use of different cell environments, such as growing …
L (−)-Carnitine production with immobilized Escherichia coli cells in continuous reactors
Escherichia coli 044 K74 was able to biotransform trans-crotonobetaine to l (−)-carnitine in
continuous packed-bed reactors with cells immobilized in glass beads or polyurethane …
continuous packed-bed reactors with cells immobilized in glass beads or polyurethane …
Process integration aspects for the production of fine chemicals illustrated with the biotransformation of γ-butyrobetaine into l-carnitine
FW Hoeks, J Mühle, L Böhlen, I Pšenička - The Chemical Engineering …, 1996 - Elsevier
l-carnitine is a fine chemical with pharmaceutical, nutritional and animal food applications.
Thus, the product purification forms an essential part of the production process …
Thus, the product purification forms an essential part of the production process …
Metabolic engineering for high yielding L(-)-carnitine production in Escherichia coli
Abstract Background L (-)-carnitine production has been widely studied because of its
beneficial properties on various diseases and dysfunctions. Enterobacteria possess a …
beneficial properties on various diseases and dysfunctions. Enterobacteria possess a …