Ovarian cancer progression involves multifaceted and variable tumor microenvironments
(TMEs), from the in situ carcinoma in the fallopian tube or ovary to dissemination into the …

Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

New models for epithelial ovarian cancer initiation and metastasis are required to obtain a
mechanistic understanding of the disease and to develop new therapeutics. Modeling …

Epithelial ovarian cancers (EOCs) are the leading cause of death from gynecological
malignancy in Western societies. Despite advances in surgical treatments and improved …

Intractable human diseases such as cancers, are context dependent, unique to both the
individual patient and to the specific tumor microenvironment. However, conventional cancer …

Simple Summary The tumor-surrounding niche comprises not only cancer cells but also
stromal cells, signaling molecules, secreted factors and the extracellular matrix. This niche …

Simple Summary Ovarian cancer is one of the most lethal female cancers. Numerous
investigations into the development and progression of this disease have resulted in the …

For many cancers, there is a real need for more effective therapies. Although many drugs
show promising results in vitro, most fail to translate into an in vivo model system, and only∼ …

The pattern of ovarian cancer metastasis is markedly different from that of most other
epithelial tumors, because it rarely spreads hematogenously. Instead, ovarian cancer cells …

Reliable and predictive experimental models are urgently needed to study metastatic
mechanisms of ovarian cancer cells in the omentum. Although models for ovarian cancer …