The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …

Calcineurin modulates environmental stress survival and virulence of the human fungal
pathogen Cryptococcus neoformans. Previously, we identified 44 putative calcineurin …

The endoplasmic reticulum (ER) is a central hub where secreted or membrane-bound
proteins are maturated and folded properly in eukaryotes. Maintenance of ER homeostasis …

The underlying mechanism of thermotolerance, which is a key virulence factor essential for
pathogenic fungi such as Cryptococcus neoformans, is largely unexplored. In this study, our …

In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under
stress conditions. During temperature adaptation in the human fungal pathogen …

Adaptation to host temperature is a prerequisite for any pathogen capable of causing deep
infection in humans. Our previous studies demonstrated that a Cryptococcus neoformans …

Across lower eukaryotes, the transcription factor Crz1 is dephosphorylated by calcineurin,
which facilitates Crz1 translocation to the nucleus to regulate gene expression. In the fungal …

Eukaryotic cells utilize complex signaling systems to detect their environments, responding
and adapting as new conditions arise during evolution. The basidiomycete fungus …

Casein kinases regulate a wide range of cellular functions in eukaryotes, including
phosphorylation of proteins that are substrates for degradation via the ubiquitin-proteasome …

Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival,
and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse …