Chemoenzymatic synthesis of homogeneous chondroitin polymers and its derivatives

Y Wang, S Li, X Xu, Y Tan, X Liu, J Fang - Carbohydrate polymers, 2020 - Elsevier
Chondroitin sulfate is a linear glycosaminoglycan widely distributed as an important
extracellular matrix component of mammalian cells. It participates in numerous pathological …

Robust one-pot multi-enzyme polysaccharide remodeling strategy for the synthesis of uniform chondroitin fragments and derivatives

L Yang, X Xu, S Li, Y Li, P Ling, J Fang - Carbohydrate Research, 2021 - Elsevier
The non-sulfated chondroitin backbone (CH) is the synthetic precursor of chondroitin sulfate,
a linear polysaccharide with dramatic biological functions. Owing to the intrinsic …

Recent advances in the chemical and enzymatic chondroitin sulfate synthesis

A Vibert, JC Jacquinet, C Lopin-Bon - Journal of Carbohydrate …, 2011 - Taylor & Francis
Chondroitin sulfates (CSs) are complex polysaccharides that play important roles in many
biological processes. This mini-review focuses on the recent advances in chemical and …

Semisynthesis of chondroitin sulfate oligosaccharides based on the enzymatic degradation of chondroitin

X Zhang, H Liu, W Yao, X Meng, Z Li - The Journal of organic …, 2019 - ACS Publications
Chondroitin sulfate (CS) is a structurally complex polyanionic glycosaminoglycan that plays
essential roles in physiological processes. Here we report a facile approach to a library of …

Synthesis of structurally defined chondroitin sulfate: Paving the way to the structure-activity relationship studies

Y Ji, S Zhang, M Qiao, R Jiao, J Li, P Song… - Carbohydrate …, 2020 - Elsevier
Chondroitin sulfate (CS) is one of the major and widespread glycosaminoglycans, a family of
structurally complex, linear, anionic hetero-co-polysaccharides. CS plays a vital role in …

[HTML][HTML] Enzymatic production of chondroitin oligosaccharides and its sulfate derivatives

W Zhang, R Xu, X Jin, Y Wang, L Hu… - … in Bioengineering and …, 2022 - frontiersin.org
Chondroitin sulfate (CS) has a wide range of physiological functions and clinical
applications. However, the biosynthesis of chondroitin oligosaccharides (o-CHs) and sulfate …

Enzymatic synthesis of chondroitin 4-sulfate with well-defined structure

S Fujikawa, M Ohmae, S Kobayashi - Biomacromolecules, 2005 - ACS Publications
Synthesis of chondroitin sulfate (ChS) with well-defined structure was achieved for the first
time by hyaluronidase-catalyzed polymerization. N-Acetylchondrosine (GlcAβ (1→ 3) …

Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides

W Zhang, R Xu, J Chen, H Xiong, Y Wang… - International journal of …, 2023 - Elsevier
Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …

Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides

J Li, G Su, J Liu - Angewandte Chemie International Edition, 2017 - Wiley Online Library
Chondroitin sulfate (CS) is a sulfated polysaccharide that plays essential physiological roles.
Here, we report an enzyme‐based method for the synthesis of a library of 15 different CS …

Biotechnological advances in the synthesis of modified chondroitin towards novel biomedical applications

D Cimini, E Bedini, C Schiraldi - Biotechnology Advances, 2023 - Elsevier
Chondroitin sulfate (CS) is a well-known glycosaminoglycan present in a large variety of
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …