PDAC-ANN: an artificial neural network to predict pancreatic ductal adenocarcinoma based on gene expression

PP Almeida, CP Cardoso, LM de Freitas - BMC cancer, 2020 - Springer
Background Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality
and metastatic potential, there is a lack of effective therapies and a low survival rate for this …

Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma

Y Xiao, B Zhang, JM Cloyd, G Xu, S Du, Y Mao… - Surgical Oncology, 2022 - Elsevier
Introduction The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is
highly variable and there is a paucity of effective treatment options for patients with PDAC …

[HTML][HTML] Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis

Y Tang, Z Zhang, Y Tang, X Chen… - Oncology …, 2018 - spandidos-publications.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most complicated and fatally
pathogenic human malignancies. Therefore, there is an urgent need to improve our …

Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel subtypes

L Zhao, H Zhao, H Yan - BMC cancer, 2018 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of
cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC …

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma

S Haider, J Wang, A Nagano, A Desai, P Arumugam… - Genome medicine, 2014 - Springer
Background Improved usage of the repertoires of pancreatic ductal adenocarcinoma
(PDAC) profiles is crucially needed to guide the development of predictive and prognostic …

Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development

M Giulietti, G Occhipinti, G Principato, F Piva - Cellular Oncology, 2016 - Springer
Purpose Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Up
till now, the patient's prognosis remains poor which, among others, is due to the paucity of …

[HTML][HTML] Development and validation of a 7-gene prognostic signature to improve survival prediction in pancreatic ductal adenocarcinoma

Z Feng, H Qian, K Li, J Lou, Y Wu… - Frontiers in Molecular …, 2021 - frontiersin.org
Background: Previous prognostic signatures of pancreatic ductal adenocarcinoma (PDAC)
are mainly constructed to predict the overall survival (OS), and their predictive accuracy …

Construction of a prognostic prediction system for pancreatic ductal adenocarcinoma to investigate the key prognostic genes

B Zheng, J Peng, A Mollayup… - Molecular …, 2018 - spandidos-publications.com
Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses.
Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of …

[HTML][HTML] Identifying drug targets in pancreatic ductal adenocarcinoma through machine learning, analyzing biomolecular networks, and structural modeling

W Yan, X Liu, Y Wang, S Han, F Wang, X Liu… - Frontiers in …, 2020 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related
death and has an extremely poor prognosis. Thus, identifying new disease-associated …

Identification and validation of a diagnostic and prognostic multi-gene biomarker panel for pancreatic ductal adenocarcinoma

H Klett, H Fuellgraf, E Levit-Zerdoun, S Hussung… - Frontiers in …, 2018 - frontiersin.org
Late diagnosis and systemic dissemination essentially contribute to the invariably poor
prognosis of pancreatic ductal adenocarcinoma (PDAC). Therefore, the development of …