Genetic models suggested that SMARCA5 was required for DNA templated events including
transcription, DNA replication and DNA repair. We engineered a degron tag into the …

Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …

In vertebrates, SMARCAD1 participates in transcriptional regulation, heterochromatin
maintenance, DNA repair, and replication. The molecular basis underlying its involvement in …

The ATP-dependent chromatin remodeler SMARCAD1 acts on nucleosomes during DNA
repair and transcription, but despite its implication in disease, information on its structure …

Maintaining chromatin structure is a complex and dynamic process. The ability to regulate
this is essential for appropriate DNA compaction, transcription, DNA-replication, and DNA …

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Epigenetic marks such as posttranslational histone modifications specify the functional
states of underlying DNA sequences, though how they are maintained after their disruption …

Smarca5, an ATPase of the ISWI class of chromatin remodelers, is a key regulator of
chromatin structure, cell cycle and DNA repair. Smarca5 is deregulated in leukemia and …

ATP-dependent chromatin remodellers represent a class of proteins that restructure
chromatin through the action of a conserved helicase-like ATPase domain. Remodellers …

Genomic studies performed in cancer patients and tumor-derived cell lines have identified a
high frequency of alterations in components of the mammalian switch/sucrose non …